New Drug Evaluations are concise, structured reviews of new drugs recently launched within the NHS. These documents seek to provide a brief overview of the efficacy, safety and cost of new drugs.

Naldemedine is the second oral peripherally acting μ-opioid receptor antagonist to be launched,
after naloxegol. It is licensed for the treatment of opioid induced constipation (OIC) in adults who
have previously been treated with laxatives.

This review is older than 18 months; in view of the continued emergence of new evidence, readers are recommended to re-check the biomedical literature.

NICE has accredited the process used by the Regional Drug and Therapeutics Centre to produce New Drug Evaluations. Accreditation is valid until the 30th of June 2024.
For more information visit www.nice.org/accreditation