This a new RDTC publication to aid clinical decision making when choosing the most appropriate DOAC for an individual patient with atrial fibrillation.

It has been prepared in response to the NHSE England National Procurement and Commissioning Recommendations published in January 2022.

This publication was updated in August 2022 to update guidance on use of DOACs in patients with AF with prosthetic heart valves. Further information was also added about use in extremes of bodyweight.